LeHavreV1, Main, Exploration, bibRecord, 000635

Different Modalities of Intercellular Membrane Exchanges Mediate Cell-to-cell P-glycoprotein Transfers in MCF-7 Breast Cancer Cells*

Identifieur interne : 000635 ( Main/Exploration ); précédent : 000634; suivant : 000636

Different Modalities of Intercellular Membrane Exchanges Mediate Cell-to-cell P-glycoprotein Transfers in MCF-7 Breast Cancer Cells*

Auteurs : Jennifer Pasquier [France] ; Ludovic Galas [France] ; Céline Boulangé-Lecomte ; Damien Rioult ; Florence Bultelle ; Pierre Magal [France] ; Glenn Webb ; Frank Le Foll

Source :

The Journal of Biological Chemistry [ 0021-9258 ] ; 2012.

RBID : PMC:3293537

English descriptors

KwdEn :
- Breast Neoplasms (genetics), Breast Neoplasms (metabolism), Breast Neoplasms (pathology), Cell Communication, Cell Line, Tumor, Cell-Derived Microparticles (genetics), Cell-Derived Microparticles (metabolism), Cell-Derived Microparticles (pathology), Drug Resistance, Neoplasm, Female, Humans, P-Glycoprotein (genetics), P-Glycoprotein (metabolism), Protein Transport (genetics).
MESH :
- chemical , genetics : P-Glycoprotein.
- genetics : Breast Neoplasms, Cell-Derived Microparticles, Protein Transport.
- metabolism : Breast Neoplasms, Cell-Derived Microparticles, P-Glycoprotein.
- pathology : Breast Neoplasms, Cell-Derived Microparticles.
- Cell Communication, Cell Line, Tumor, Drug Resistance, Neoplasm, Female, Humans.

Abstract

Background: The P-glycoprotein is expressed in many human cancers, where it contributes to multi-drug resistance phenomenon.

Results: Both TnTs and microparticles contribute to the transfer of P-gp in MCF-7.

Conclusion: Our findings supply new mechanistic evidences for the extragenetic emergence of MDR in cancer cells.

Significance: Inhibition of both MPs and TnTs could be included in treatment strategies designed to overcome MDR.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3293537

DOI: 10.1074/jbc.M111.312157
PubMed: 22228759
PubMed Central: 3293537

Affiliations:

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Different Modalities of Intercellular Membrane Exchanges Mediate Cell-to-cell P-glycoprotein Transfers in MCF-7 Breast Cancer Cells<xref ref-type="fn" rid="FN1">*</xref>
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<series><title level="j">The Journal of Biological Chemistry</title>
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<term>Cell Communication</term>
<term>Cell Line, Tumor</term>
<term>Cell-Derived Microparticles (genetics)</term>
<term>Cell-Derived Microparticles (metabolism)</term>
<term>Cell-Derived Microparticles (pathology)</term>
<term>Drug Resistance, Neoplasm</term>
<term>Female</term>
<term>Humans</term>
<term>P-Glycoprotein (genetics)</term>
<term>P-Glycoprotein (metabolism)</term>
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<term>Cell-Derived Microparticles</term>
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<term>Cell-Derived Microparticles</term>
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<term>Cell-Derived Microparticles</term>
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<front><div type="abstract" xml:lang="en"><p><bold>Background:</bold>
 The P-glycoprotein is expressed in many human cancers, where it contributes to multi-drug resistance phenomenon.</p>
<p><bold>Results:</bold>
 Both TnTs and microparticles contribute to the transfer of P-gp in MCF-7.</p>
<p><bold>Conclusion:</bold>
 Our findings supply new mechanistic evidences for the extragenetic emergence of MDR in cancer cells.</p>
<p><bold>Significance:</bold>
 Inhibition of both MPs and TnTs could be included in treatment strategies designed to overcome MDR.</p>
</div>
</front>
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Different Modalities of Intercellular Membrane Exchanges Mediate Cell-to-cell P-glycoprotein Transfers in MCF-7 Breast Cancer Cells*

Different Modalities of Intercellular Membrane Exchanges Mediate Cell-to-cell P-glycoprotein Transfers in MCF-7 Breast Cancer Cells*

Source :

English descriptors

Abstract

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